Fundamentholfundamenthol

Drugs and Alcohol Abuse

BiologyHuman Health and DiseaseFor NEET aspirants

Drugs and alcohol abuse harms health, family and society, and it often begins in adolescence. This page covers opioids such as heroin and morphine, cannabinoids, cocaine, hallucinogenic plants, misused medicines, tobacco and nicotine, the causes of abuse among adolescents, addiction and dependence, harmful effects including those of anabolic steroids, and ways to prevent abuse, as in the NCERT Class 12 chapter Human Health and Disease. NEET often asks about drug, source and effect pairs and steroid side effects in questions on drugs and alcohol abuse.

On this page1Overview2Opioids3Cannabinoids4Cocaine and hallucinogens5Misused medicines6Tobacco7Adolescence8Addiction and dependence9Effects10Prevention11Exam essentials12Quick revision13Solved examples14Practice
Key Points at a Glance
  1. ★ Must learn Commonly abused drugs: opioids, cannabinoids and coca alkaloids; most come from flowering plants, some from fungi.
  2. ★ Must learn Heroin (smack) is diacetylmorphine, made by acetylation of morphine from the latex of Papaver somniferum; it is a depressant.
  3. Opioids bind to opioid receptors in the central nervous system and gastrointestinal tract.
  4. Cannabinoids (marijuana, hashish, charas, ganja) come from Cannabis sativa; they act on receptors in the brain and affect the cardiovascular system.
  5. ★ Must learn Cocaine (coke, crack) from Erythroxylum coca interferes with the transport of dopamine; it is a CNS stimulant.
  6. Hallucinogenic plants: Atropa belladonna and Datura.
  7. Nicotine stimulates the adrenal gland to release adrenaline and nor-adrenaline, raising blood pressure and heart rate.
  8. Smoking raises blood CO and lowers haem-bound oxygen.
  9. Adolescence: about 12-18 years; a bridge between childhood and adulthood.
  10. ★ Must learn Addiction: psychological attachment to drug effects; dependence: withdrawal syndrome when the drug is stopped abruptly.
  11. ★ Must learn Anabolic steroids: masculinisation in females; smaller testicles and decreased sperm production in males; stunted growth in adolescents.
  12. Prevention: avoid undue peer pressure, education and counselling, help from parents and peers, danger signs, professional help.

1. Drug and Alcohol Abuse: An Overview

  • Surveys and statistics show that the use of drugs and alcohol is rising, especially among the youth.
  • This is a cause of concern, because it can result in many harmful effects.
  • Proper education and guidance help youth safeguard themselves against these dangerous behaviour patterns and follow healthy life styles.
  • ★ Exam imp The drugs commonly abused are opioids, cannabinoids and coca alkaloids.
  • The majority of these come from flowering plants; some come from fungi.
Memory Trick

Only Careless Choices: Opioids, Cannabinoids, Coca alkaloids, the three groups of commonly abused drugs.

2. Opioids

  • Opioids: drugs that bind to specific opioid receptors present in the central nervous system and the gastrointestinal tract.
  • ★ Exam imp Heroin, commonly called smack, is chemically diacetylmorphine.
  • Heroin is a white, odourless, bitter crystalline compound.
  • It is obtained by acetylation of morphine.
  • ★ Exam imp Morphine is extracted from the latex of the poppy plant, Papaver somniferum.
  • Heroin is generally taken by snorting and injection.
  • ★ Exam imp Heroin is a depressant: it slows down body functions.
Chemical structure of morphine Skeletal structure of morphine: a benzene ring carrying a hydroxyl group (HO) at the top left, fused to two six-membered carbon rings, with an oxygen bridge (O) between the benzene ring and the lower ring. The lower ring carries a hydrogen (H) on a solid wedge, a hydroxyl group (HO) on a hashed wedge and one double bond. A bold two-carbon bridge passes in front to a nitrogen atom (N) carrying a methyl group (CH3), closing a ring containing nitrogen. O N CH3 HO HO H
Figure 1: Chemical structure of morphine. Acetylation of morphine gives heroin, chemically diacetylmorphine.
Opium poppy, Papaver somniferum A black ink drawing of the opium poppy. Deeply lobed, toothed leaves clasp the stem; a nodding flower bud hangs from a curved stalk; a tall stalk carries an open flower with broad, rounded petals around a ring of many stamens. Beside it is a separate rounded seed capsule (the fruit) with ridges down its sides and a flat, rayed disc on top.
Figure 2: Opium poppy, Papaver somniferum. Morphine is extracted from the latex of this plant.
★ Very important Heroin = smack = diacetylmorphine. It is made by acetylation of morphine, which comes from the latex of the poppy, and it acts as a depressant.
Memory Trick

Poppy Makes Heroin: Poppy latex gives Morphine; acetylating morphine gives Heroin.

Key idea
Opioids act on receptors in the CNS and gut; heroin, made from poppy morphine, depresses body functions.

3. Cannabinoids

  • Cannabinoids: a group of chemicals that interact with cannabinoid receptors, present principally in the brain.
  • ★ Exam imp Natural cannabinoids are obtained from the inflorescences of the plant Cannabis sativa.
  • ★ Exam imp The flower tops, leaves and resin of the cannabis plant are used in various combinations to produce marijuana, hashish, charas and ganja.
  • Cannabinoids are generally taken by inhalation and oral ingestion.
  • They are known for their effects on the cardiovascular system of the body.
  • These days, cannabinoids are also being abused by some sportspersons.
Skeletal structure of a cannabinoid molecule Skeletal structure of a cannabinoid molecule: a benzene ring carrying two hydroxyl groups (OH), a straight five-carbon chain on one side, and on the other a ten-carbon branched chain with two carbon-carbon double bonds and methyl branches, joined to the ring carbon between the two hydroxyl groups. OH HO
Figure 3: Skeletal structure of a cannabinoid molecule. Cannabinoids act on cannabinoid receptors, present mainly in the brain.
Leaf of Cannabis sativa A black ink drawing of a single palmately compound leaf of Cannabis sativa: seven long, narrow, pointed leaflets with sharply toothed margins spread like fingers from the top of a long leaf stalk, the middle leaflet the longest.
Figure 4: Leaves of Cannabis sativa. Its flower tops, leaves and resin are used to make marijuana, hashish, charas and ganja.
Memory Trick

My Heart Can't Go: Marijuana, Hashish, Charas, Ganja, the cannabis products, which act on the heart and blood vessels (cardiovascular system).

Key idea
Cannabinoids from Cannabis sativa act on brain receptors and affect the cardiovascular system.

4. Coca Alkaloids and Hallucinogens

  • Coca alkaloid, or cocaine, is obtained from the coca plant Erythroxylum coca, native to South America.
  • ★ Exam imp Cocaine interferes with the transport of the neurotransmitter dopamine.
  • Cocaine is commonly called coke or crack, and is usually snorted.
  • ★ Exam imp It has a potent stimulating action on the central nervous system, producing a sense of euphoria and increased energy.
  • Excessive dosage of cocaine causes hallucinations.
  • Other well-known plants with hallucinogenic properties: Atropa belladonna and Datura.
Flowering branch of Datura A black ink drawing of a leafy branch of Datura. Broad leaves with wavy, sharply toothed margins grow along the stem. At the top, a long, trumpet-shaped flower with a long tube and a flared, pointed rim slants upwards. Lower on the stem is a round fruit covered in sharp spines.
Figure 5: Flowering branch of Datura, a plant with hallucinogenic properties.
Heroin (an opioid)
  • From morphine, from poppy latex.
  • Binds opioid receptors in the CNS and gut.
  • A depressant: slows down body functions.
  • Taken by snorting and injection.
Cocaine (a coca alkaloid)
  • From Erythroxylum coca.
  • Interferes with dopamine transport.
  • A stimulant: euphoria and increased energy.
  • Usually snorted; excess causes hallucinations.
NEET Focus

Match each drug to its target. Opioids: opioid receptors in the CNS and gastrointestinal tract. Cannabinoids: cannabinoid receptors, mainly in the brain, with cardiovascular effects. Cocaine: dopamine transport. Heroin depresses; cocaine stimulates. A statement calling heroin a stimulant is false.

Quick Recall: tap to check
Which plant gives the latex from which morphine is extracted?
The poppy, Papaver somniferum.
What is heroin chemically, and what is its common name?
Diacetylmorphine; it is commonly called smack.
Where are cannabinoid receptors principally present?
In the brain.
Which neurotransmitter's transport does cocaine interfere with?
Dopamine.
Name two plants with hallucinogenic properties.
Atropa belladonna and Datura.
Key idea
Cocaine stimulates the CNS by interfering with dopamine transport; Atropa belladonna and Datura are hallucinogenic.

5. Medicines that are Abused

  • Drugs such as barbiturates, amphetamines and benzodiazepines are normally used as medicines.
  • They help patients cope with mental illnesses such as depression and insomnia, but they are often abused.
  • ★ Exam imp Morphine is a very effective sedative and painkiller, very useful in patients who have undergone surgery.
  • Several plants, fruits and seeds with hallucinogenic properties have been used for hundreds of years in folk medicine, religious ceremonies and rituals all over the globe.
★ Very important Drug abuse: taking a drug for a purpose other than medicinal use, or in amounts or frequency that impair one's physical, physiological or psychological functions.
Key idea
Many abused drugs are useful medicines; abuse lies in the purpose, amount or frequency of use.

6. Tobacco and Smoking

  • Smoking also paves the way to hard drugs.
  • Tobacco has been used by human beings for more than 400 years; it is smoked, chewed or used as snuff.
  • Tobacco contains a large number of chemical substances, including nicotine, an alkaloid.
  • ★ Exam imp Nicotine stimulates the adrenal gland to release adrenaline and nor-adrenaline into the blood; both raise blood pressure and increase heart rate.
  • Smoking is associated with increased incidence of cancers of the lung, urinary bladder and throat, and with bronchitis, emphysema, coronary heart disease, gastric ulcer, etc.
  • ★ Exam imp Tobacco chewing is associated with increased risk of cancer of the oral cavity.
  • ★ Exam imp Smoking increases the carbon monoxide (CO) content of blood and reduces the concentration of haem-bound oxygen, causing oxygen deficiency in the body.
  • Cigarette packets carry a statutory warning that smoking is injurious to health, yet smoking is common among young and old.
  • Knowing the dangers and addictive nature of smoking and chewing tobacco, young and old should avoid these habits.
  • Any addict needs counselling and medical help to get rid of the habit.
Memory Trick

Nicotine Needs the Adrenal: nicotine acts on the adrenal gland, whose adrenaline and nor-adrenaline raise pressure and pulse.

Key idea
Nicotine raises blood pressure and heart rate through adrenal hormones; smoking adds CO to blood and causes many cancers.

7. Adolescence and Drug/Alcohol Abuse

  • Adolescence means both 'a period' and 'a process' during which a child becomes mature in attitudes and beliefs for effective participation in society.
  • ★ Exam imp The period between 12-18 years of age may be thought of as the adolescence period.
  • Adolescence is a bridge linking childhood and adulthood.
  • It is accompanied by several biological and behavioural changes, so it is a very vulnerable phase of mental and psychological development.

7.1 Why youngsters start

  • Curiosity, need for adventure and excitement, and experimentation are common causes.
  • A child's natural curiosity motivates experiments; effects of alcohol or drugs that are perceived as benefits complicate this further.
  • The first use may be out of curiosity or experimentation; later the child uses these to escape facing problems.
  • Stress from pressure to excel in academics, examinations and competitions has played a significant role; drugs are often tried for perceived benefits such as relief from stress.
  • The perception that it is 'cool' or progressive to smoke or use drugs or alcohol is a major cause; television, movies, newspapers and the internet help to promote it.
  • Other associated factors: unstable or unsupportive family structures and peer pressure.
Key idea
Adolescence (12-18 years) is vulnerable; curiosity, stress, the 'cool' image, weak family support and peer pressure push youngsters towards drugs.

8. Addiction and Dependence

  • Because of perceived benefits, drugs are frequently used repeatedly.
  • Most users fail to realise the inherent addictive nature of alcohol and drugs.
★ Very important Addiction: a psychological attachment to certain effects, such as euphoria and a temporary feeling of well-being, associated with drugs and alcohol.
  • These effects drive people to take drugs even when they are not needed, or even when their use becomes self-destructive.

8.1 The vicious circle of addiction

  1. Drugs or alcohol are used repeatedly.
  2. The tolerance level of the receptors in the body increases.
  3. The receptors now respond only to higher doses.
  4. This leads to greater intake and to addiction.
  5. The user is pulled into regular use (abuse), from which he or she may not be able to get out.
  • ★ Exam imp Use of these drugs even once can be a forerunner to addiction.
  • Without guidance or counselling, the person gets addicted and becomes dependent on their use.

8.2 Dependence

  • ★ Exam imp Dependence: the tendency of the body to show a characteristic and unpleasant withdrawal syndrome if the regular dose of drugs or alcohol is abruptly discontinued.
  • Withdrawal syndrome: anxiety, shakiness, nausea and sweating, which may be relieved when use is resumed.
  • In some cases withdrawal symptoms are severe, even life-threatening, and the person may need medical supervision.
  • Dependence leads the patient to ignore all social norms to get enough funds, causing many social adjustment problems.
Addiction
  • A psychological attachment.
  • To effects such as euphoria and a temporary feeling of well-being.
  • Builds as receptor tolerance rises.
Dependence
  • A tendency of the body.
  • Shows a withdrawal syndrome when the drug is stopped abruptly.
  • Anxiety, shakiness, nausea, sweating.
Key idea
Rising receptor tolerance drives addiction; dependence shows itself as a withdrawal syndrome when the drug is stopped.

9. Effects of Drug/Alcohol Abuse

9.1 Immediate effects

  • Reckless behaviour, vandalism and violence.
  • ★ Exam imp Excessive doses may lead to coma and death due to respiratory failure, heart failure or cerebral hemorrhage.
  • A combination of drugs, or drugs taken with alcohol, generally results in overdosing and even deaths.

9.2 Warning signs among youth

  • Drop in academic performance; unexplained absence from school or college.
  • Lack of interest in personal hygiene; withdrawal; isolation; depression; fatigue.
  • Aggressive and rebellious behaviour; deteriorating relationships with family and friends.
  • Loss of interest in hobbies; change in sleeping and eating habits; fluctuations in weight, appetite, etc.
Memory Trick

Watch the three Gs first: Grades fall, Gaps in attendance, Grooming neglected. Then look for changes in mood, relationships, hobbies, sleep, eating and weight.

9.3 Far-reaching effects

  • An abuser who cannot get money for drugs or alcohol may turn to stealing.
  • A drug or alcohol addict may cause mental and financial distress to his or her entire family and friends.
  • ★ Exam imp People who take drugs intravenously (injection into a vein with a needle and syringe) are much more likely to acquire AIDS and hepatitis B.
  • The viruses of these diseases pass from one person to another through shared infected needles and syringes.
  • AIDS and hepatitis B are both chronic infections and ultimately fatal; both can also be transmitted through sexual contact or infected blood.
  • Use of alcohol during adolescence may lead to heavy drinking in adulthood.
  • ★ Exam imp Chronic use of drugs and alcohol damages the nervous system and the liver (cirrhosis).
  • Use of drugs and alcohol during pregnancy adversely affects the foetus.

9.4 Misuse of drugs in sports

  • Some sportspersons (mis)use narcotic analgesics, anabolic steroids, diuretics and certain hormones.
  • Their aim: to increase muscle strength and bulk, promote aggressiveness and so increase athletic performance.
Side effects of anabolic steroids in femalesSide effects of anabolic steroids in males
Masculinisation (features like males)Acne
Increased aggressivenessIncreased aggressiveness
Mood swings, depressionMood swings, depression
Abnormal menstrual cyclesReduction in size of the testicles
Excessive hair growth on the face and bodyDecreased sperm production
Enlargement of clitorisPotential for kidney and liver dysfunction
Deepening of voiceBreast enlargement
Premature baldness
Enlargement of the prostate gland
  • These effects may be permanent with prolonged use.
  • ★ Exam imp In adolescent males or females: severe facial and body acne, and premature closure of the growth centres of the long bones, which may stunt growth.
Tips and Tricks

In females, male features appear. Masculinisation, excessive facial and body hair, deep voice, clitoral enlargement and abnormal menstrual cycles are female effects. Smaller testicles, decreased sperm production, breast enlargement, enlarged prostate, acne and premature baldness are male effects. Aggressiveness, mood swings and depression occur in both sexes.

Quick Recall: tap to check
Name three causes of death from excessive doses of drugs.
Respiratory failure, heart failure and cerebral hemorrhage.
Which two chronic infections are common among intravenous drug users?
AIDS and hepatitis B.
Which organ does chronic alcohol use damage, causing cirrhosis?
The liver.
How do anabolic steroids cause stunted growth in adolescents?
By premature closure of the growth centres of the long bones.
Key idea
Drug abuse causes overdose deaths, infections through shared needles, liver and nervous damage, harm to the foetus, and permanent steroid side effects.

10. Prevention and Control

  • The age-old adage 'prevention is better than cure' holds true here also.
  • Smoking, drugs and alcohol are more likely to be taken up at a young age, more so during adolescence.
  • So it is best to identify the situations that may push an adolescent towards drugs or alcohol, and to take remedial measures in time.
  • Parents and teachers have a special responsibility here.
  • ★ Exam imp Parenting that combines high levels of nurturance with consistent discipline is associated with a lowered risk of substance (alcohol, drugs, tobacco) abuse.

10.1 Measures for adolescents

  1. Avoid undue peer pressure: respect and nurture each child's own choice and personality; do not push a child beyond his or her threshold limits in studies, sports or other activities.
  2. Education and counselling: teach the child to face problems and stresses, and to accept disappointments and failures as a part of life; channelise energy into sports, reading, music, yoga and other extracurricular activities.
  3. Seeking help from parents and peers: seek help immediately for proper guidance, even from close and trusted friends; this also lets the young vent feelings of anxiety and guilt.
  4. Looking for danger signs: alert parents and teachers should identify the danger signs; friends who notice drug or alcohol use should tell parents or teachers; then diagnose the malady and its causes and start remedial steps or treatment.
  5. Seeking professional and medical help: highly qualified psychologists, psychiatrists, and de-addiction and rehabilitation programmes are available; with effort and will power, the person can get rid of the problem completely and lead a normal, healthy life.
Memory Trick

Prevent Every Habit, Detect Promptly: Peer pressure (avoid), Education and counselling, Help from parents and peers, Danger signs, Professional help.

Key idea
Nurturing but disciplined parenting, counselling, support from parents and peers, watching for danger signs and professional help prevent and control abuse.

11. Exam Essentials

Pairs to Match

List IList II
HeroinSmack; diacetylmorphine; depressant
MorphineLatex of Papaver somniferum; sedative and painkiller
Opioid receptorsCentral nervous system and gastrointestinal tract
Cannabinoid receptorsPrincipally in the brain
Cannabis sativaMarijuana, hashish, charas, ganja
CannabinoidsEffects on the cardiovascular system
Erythroxylum cocaCocaine (coke, crack)
CocaineInterferes with dopamine transport
Atropa belladonna, DaturaHallucinogenic plants
Barbiturates, amphetamines, benzodiazepinesMedicines for depression and insomnia, often abused
NicotineAdrenal gland; adrenaline and nor-adrenaline
Tobacco chewingCancer of the oral cavity
SmokingMore CO, less haem-bound oxygen in blood
Chronic alcohol useLiver cirrhosis
Anabolic steroids in femalesMasculinisation
Exceptions
  • Heroin is a depressant, whereas cocaine is a stimulant.
  • Most abused drugs come from flowering plants, but some come from fungi.
  • Morphine is abused, yet it is a very effective sedative and painkiller for surgical patients.
  • Opioid receptors lie in the CNS and the gastrointestinal tract; cannabinoid receptors lie principally in the brain.
  • Addiction is psychological; dependence is shown by the body as a withdrawal syndrome.
  • Even a single use of a drug can lead to addiction.
  • Aggressiveness, mood swings and depression are steroid effects seen in both sexes.

Numbers to Remember

  • Groups of commonly abused drugs: 3 (opioids, cannabinoids, coca alkaloids).
  • Heroin: diacetylmorphine (two acetyl groups added to morphine).
  • Tobacco use by humans: more than 400 years.
  • Adolescence: 12-18 years of age.
  • Measures for prevention and control: 5.

Examples to Remember

Drug or groupSourceCommon names or productsMain action
Opioids: heroinMorphine from latex of Papaver somniferumSmackDepressant; opioid receptors in CNS and gut
CannabinoidsInflorescences of Cannabis sativaMarijuana, hashish, charas, ganjaCannabinoid receptors in brain; cardiovascular effects
Coca alkaloid: cocaineErythroxylum cocaCoke, crackStimulant; interferes with dopamine transport
HallucinogensAtropa belladonna, Datura-Hallucinations
Medicines often abused-Barbiturates, amphetamines, benzodiazepinesUsed for depression and insomnia
TobaccoTobacco plantSmoked, chewed, snuffNicotine stimulates the adrenal gland to release adrenaline and nor-adrenaline

12. Quick Revision

  • Commonly abused drugs: opioids, cannabinoids and coca alkaloids; mostly from flowering plants, some from fungi.
  • Opioids bind receptors in the CNS and gastrointestinal tract.
  • Heroin (smack) = diacetylmorphine, from acetylation of morphine; a depressant; snorted or injected.
  • Morphine comes from the latex of Papaver somniferum; it is a sedative and painkiller after surgery.
  • Cannabinoids from Cannabis sativa: marijuana, hashish, charas, ganja; inhaled or eaten; cardiovascular effects.
  • Cocaine (coke, crack) from Erythroxylum coca: blocks dopamine transport; stimulant; excess causes hallucinations.
  • Hallucinogenic plants: Atropa belladonna, Datura; barbiturates, amphetamines and benzodiazepines are misused medicines.
  • Drug abuse: use for non-medicinal purposes, or in amounts or frequency that impair body or mind.
  • Nicotine: adrenaline and nor-adrenaline raise BP and heart rate; smoking adds CO to blood; many cancers.
  • Adolescence: 12-18 years; curiosity, stress, the 'cool' image, family problems and peer pressure lead to abuse.
  • Addiction: psychological attachment; rising receptor tolerance; dependence: withdrawal syndrome.
  • Overdose: coma, death by respiratory failure, heart failure or cerebral hemorrhage.
  • IV drug users risk AIDS and hepatitis B; chronic use damages nerves and liver (cirrhosis); harms the foetus.
  • Anabolic steroids: masculinisation in females; small testicles, less sperm, breast enlargement in males; stunted growth in adolescents.
  • Prevention: avoid peer pressure, educate and counsel, seek help, watch danger signs, get professional help.

13. Solved Examples

Solved Example 1
Match List I with List II.
List I: A. Heroin, B. Cannabinoids, C. Cocaine, D. Nicotine
List II: I. Interferes with dopamine transport, II. Stimulates the adrenal gland, III. Slows down body functions, IV. Affects the cardiovascular system
Choose the correct answer:
(A) A-III, B-IV, C-I, D-II
(B) A-IV, B-III, C-I, D-II
(C) A-III, B-IV, C-II, D-I
(D) A-I, B-IV, C-III, D-II
Solution:

Answer: (A). Heroin is a depressant (III), cannabinoids affect the cardiovascular system (IV), cocaine interferes with dopamine transport (I) and nicotine stimulates the adrenal gland (II).

Solved Example 2
Read the statements.
A. Heroin is obtained by acetylation of morphine.
B. Opioid receptors are present only in the brain.
C. Cocaine is obtained from Erythroxylum coca.
D. Natural cannabinoids are obtained from the roots of Cannabis sativa.
E. Datura has hallucinogenic properties.
Choose the correct answer:
(A) A, B and C only
(B) A, C and E only
(C) B, D and E only
(D) A, D and E only
Solution:

Answer: (B). B is wrong: opioid receptors are in the CNS and gastrointestinal tract. D is wrong: natural cannabinoids come from the inflorescences.

Solved Example 3
Arrange the steps leading to addiction in the correct order.
A. Receptors respond only to higher doses
B. Repeated use of the drug
C. Greater intake and addiction
D. Tolerance level of the receptors increases
Choose the correct answer:
(A) B, A, D, C
(B) B, D, A, C
(C) D, B, A, C
(D) B, D, C, A
Solution:

Answer: (B). Repeated use (B) raises receptor tolerance (D), so receptors respond only to higher doses (A), which leads to greater intake and addiction (C).

Solved Example 4
Which of the following is NOT a side effect of anabolic steroids in males?
(A) Reduction in size of the testicles
(B) Breast enlargement
(C) Deepening of voice
(D) Premature baldness
Solution:

Answer: (C). Deepening of voice is listed among the side effects in females. The other three occur in males.

Solved Example 5
Smoking causes oxygen deficiency in the body because it:
(A) Destroys red blood cells
(B) Increases carbon monoxide in blood and reduces haem-bound oxygen
(C) Stimulates the release of adrenaline
(D) Blocks dopamine transport
Solution:

Answer: (B). Smoking raises the CO content of blood and lowers the concentration of haem-bound oxygen.

14. Practice Questions

Practice Questions
  1. Match List I with List II.
    List I: A. Papaver somniferum, B. Cannabis sativa, C. Erythroxylum coca, D. Atropa belladonna
    List II: I. Hallucinogenic plant, II. Cocaine, III. Morphine, IV. Hashish and ganja
    (A) A-III, B-IV, C-II, D-I
    (B) A-IV, B-III, C-II, D-I
    (C) A-III, B-II, C-IV, D-I
    (D) A-I, B-IV, C-II, D-IIIAnswer: (A). Poppy gives morphine, cannabis gives hashish and ganja, coca gives cocaine, and Atropa belladonna is hallucinogenic.
  2. Read the statements.
    A. Dependence shows as a withdrawal syndrome when a regular dose is stopped abruptly.
    B. Withdrawal symptoms include anxiety, shakiness, nausea and sweating.
    C. Addiction can never follow a single use of a drug.
    D. Severe withdrawal may need medical supervision.
    (A) A, B and D only
    (B) A and C only
    (C) B, C and D only
    (D) A, B, C and DAnswer: (A). C is wrong: even one use can be a forerunner to addiction.
  3. Arrange the steps from the poppy plant to heroin in the correct order.
    A. Morphine is acetylated
    B. Latex is obtained from Papaver somniferum
    C. Heroin (diacetylmorphine) is formed
    D. Morphine is extracted from the latex
    (A) B, D, A, C
    (B) D, B, A, C
    (C) B, A, D, C
    (D) B, D, C, AAnswer: (A). Latex, then morphine extraction, then acetylation, which gives heroin.
  4. Which of the following is NOT a common warning sign of drug or alcohol abuse among youth?
    (A) Drop in academic performance
    (B) Lack of interest in personal hygiene
    (C) Steady improvement in relationships with family
    (D) Change in sleeping and eating habitsAnswer: (C). Relationships with family and friends deteriorate.
  5. Statement I: Nicotine stimulates the adrenal gland to release adrenaline and nor-adrenaline.
    Statement II: Adrenaline and nor-adrenaline lower blood pressure.
    (A) Both statements are correct
    (B) Both statements are incorrect
    (C) Statement I is correct but Statement II is incorrect
    (D) Statement I is incorrect but Statement II is correctAnswer: (C). Both hormones raise blood pressure and increase heart rate.
  6. Which two infections are more likely in people who take drugs intravenously?
    (A) Typhoid and cholera
    (B) AIDS and hepatitis B
    (C) Malaria and dengue
    (D) Ringworm and pneumoniaAnswer: (B). Shared infected needles and syringes transfer the viruses of AIDS and hepatitis B.
  7. Chronic use of alcohol damages the liver, causing:
    (A) Emphysema
    (B) Cirrhosis
    (C) Bronchitis
    (D) Gastric ulcerAnswer: (B). Cirrhosis of the liver.
Practice Questions: Short Answer
  1. List the harmful effects caused by alcohol or drug abuse.Answer: Reckless behaviour, vandalism and violence; coma and death from overdose (respiratory failure, heart failure, cerebral hemorrhage); stealing; distress to family; AIDS and hepatitis B through shared needles; damage to the nervous system and liver (cirrhosis); harm to the foetus; permanent side effects of anabolic steroids.
  2. Can friends influence one to take alcohol or drugs? If so, how can one protect oneself?Answer: Yes, peer pressure is a major factor. One can avoid undue pressure, seek help and guidance from parents and close, trusted friends, take counselling to face stress and failure, channel energy into sports, reading, music and yoga, and seek professional help if needed.
  3. Why is it difficult to give up alcohol or drugs once a person starts?Answer: Their addictive nature: repeated use raises the tolerance of receptors, so higher doses are needed, which pulls the user into a vicious circle. Dependence also develops, so stopping abruptly brings an unpleasant withdrawal syndrome that is relieved only by resuming use.
  4. What motivates youngsters to take alcohol or drugs, and how can this be avoided?Answer: Curiosity, adventure, experimentation, perceived benefits, escape from problems, academic stress, the 'cool' image promoted by media, unsupportive families and peer pressure. It can be avoided by nurturing but disciplined parenting, avoiding undue pressure, education and counselling, help from parents and peers, watching for danger signs and professional help.

Common Mistakes to Avoid

Watch out
  • Calling heroin a stimulant. Heroin is a depressant; cocaine is the stimulant.
  • Saying heroin is extracted directly from poppy latex. Morphine is extracted from the latex; heroin is made by acetylating morphine.
  • Placing opioid receptors only in the brain. They lie in the CNS and the gastrointestinal tract.
  • Linking cocaine to opioid receptors. Cocaine interferes with the transport of dopamine.
  • Saying cannabinoids come from the roots of Cannabis. They come from the inflorescences; flower tops, leaves and resin are used.
  • Confusing addiction with dependence. Addiction is a psychological attachment; dependence is the body's withdrawal syndrome.
  • Writing that nicotine lowers blood pressure. Through adrenaline and nor-adrenaline, it raises blood pressure and heart rate.
  • Swapping steroid effects between the sexes. Masculinisation and deepening of voice are female effects; reduced testicle size and decreased sperm production are male effects.

Frequently Asked Questions

Which drugs are commonly abused?

The drugs commonly abused are opioids such as heroin, cannabinoids such as marijuana, hashish, charas and ganja, and coca alkaloids such as cocaine. Most come from flowering plants and some from fungi. Medicines such as barbiturates, amphetamines and benzodiazepines, used for depression and insomnia, are also often abused.

How is heroin made, and how does it act?

Morphine is extracted from the latex of the poppy, Papaver somniferum. Acetylation of morphine gives heroin, chemically diacetylmorphine, a white, odourless, bitter crystalline compound called smack. Heroin binds opioid receptors in the central nervous system and gut. It is a depressant that slows down body functions.

What are cannabinoids and what do they affect?

Cannabinoids are chemicals that act on cannabinoid receptors, present mainly in the brain. Natural cannabinoids come from the inflorescences of Cannabis sativa; its flower tops, leaves and resin give marijuana, hashish, charas and ganja. They are inhaled or eaten and are known for their effects on the cardiovascular system.

How does cocaine affect the body?

Cocaine, a coca alkaloid from Erythroxylum coca of South America, interferes with the transport of the neurotransmitter dopamine. Called coke or crack and usually snorted, it strongly stimulates the central nervous system, producing euphoria and increased energy. Excessive doses cause hallucinations.

Why is smoking harmful?

Tobacco contains nicotine, which makes the adrenal gland release adrenaline and nor-adrenaline, raising blood pressure and heart rate. Smoking is linked to cancers of the lung, urinary bladder and throat, bronchitis, emphysema, coronary heart disease and gastric ulcer. It also raises carbon monoxide in blood and reduces haem-bound oxygen.

What is the difference between addiction and dependence?

Addiction is a psychological attachment to effects such as euphoria and a temporary feeling of well-being. Repeated use raises receptor tolerance, so higher doses are needed. Dependence is the body's tendency to show a withdrawal syndrome of anxiety, shakiness, nausea and sweating when a regular dose is stopped abruptly.

What are the side effects of anabolic steroids?

In females: masculinisation, aggressiveness, mood swings, depression, abnormal menstrual cycles, excess body hair, enlarged clitoris and deep voice. In males: acne, aggressiveness, mood swings, depression, smaller testicles, less sperm, possible kidney and liver dysfunction, breast enlargement, premature baldness and enlarged prostate. Adolescents may suffer stunted growth.

How can drug and alcohol abuse be prevented among adolescents?

Avoid undue peer pressure, educate and counsel children to face stress and failure, and channel their energy into sports, reading, music and yoga. Seek help from parents and trusted friends, watch for danger signs, and use psychologists, psychiatrists and de-addiction programmes. Nurturing parenting with consistent discipline lowers the risk.

Previous year questions on Drugs and Alcohol Abuse

5 questions from past papers, each with a step-by-step solution.

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