JEE Main 2025 Apr 4 Shift 1, Chemistry Q14: Proteins

JEE Main2025Apr 4, Shift 1Chemistry

Identify the pair of reactants that upon reaction, with elimination of HCl will give rise to the dipeptide Gly-Ala.

Solution

Gly-Ala means the N-terminus is glycine and the C-terminus is alanine, with a peptide bond joining glycine's $-$ COOH to alanine's $-$ NH $_{2}$ .

To form this bond with loss of HCl, glycine must be activated as its acid chloride (Gly $-$ COCl) and alanine must retain a free $-$ NH $_{2}$ and an intact $-$ COOH (so the C-terminus remains free).

$N H_{2} - C H_{2} - C O C l + N H_{2} - C H (C H_{3}) - C O O H \to N H_{2} - C H_{2} - C O - N H - C H (C H_{3}) - C O O H + H C l$

$∴$ The matching pair is option (1).

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JEE Main 2025 Apr 4 Shift 1, Chemistry Q14: Proteins

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