Fundamentholfundamenthol
NEET2026Biology
Q.

The sixth mutant codon of beta globin gene causing polymerization of Haemoglobin and change in RBC shape is ______.

  1. A

    GUG

  2. B

    AUG

  3. C

    GAG

  4. D

    CAG

Solution

Sickle-cell anaemia results from a single base substitution at the sixth codon of the beta globin gene, changing GAG (glutamic acid) to GUG (valine). This valine substitution leads to haemoglobin polymerisation and the typical sickle-shaped RBCs.

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