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NEET 2022, Biology Q34: Recombinant DNA Technology

NEET2022Biology
Q.

If a geneticist uses the blind approach for sequencing the whole genome of an organism, followed by assignment of function to different segments, the methodology adopted by him is called as :

  1. A

    Sequence annotation

  2. B

    Gene mapping

  3. C

    Expressed sequence tags

  4. D

    Bioinformatics

Solution

Sequence annotation refers to the systematic determination of the entire genome sequence first, followed by the identification of genes and assignment of functional roles to the various DNA segments. This is the 'blind' (sequence-first, function-later) approach used in the Human Genome Project.

The alternative approach, called Expressed Sequence Tags (ESTs), focuses first on sequences that are expressed as RNA, identifying functional genes without sequencing the entire genome.

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