Statements related to human Insulin are given below. Which statements(s) is/are correct about genetically engineered Insulin?
(a) Pro-hormone insulin contain extra stretch of C-peptide
(b) A-peptide and B-peptide chains of insulin were produced separately in E.coli, extracted and combined by creating disulphide bond between them.
(c) Insulin used for treatment of Diabetes was extracted from Cattles and Pigs.
(d) Pro-hormone Insulin needs to be processed for converting into a mature and functional hormone.
(e) Some patients develop allergic reactions to the foreign insulin.
Choose the most appropriate answer from the options given below :
- A
(a), (b) and (d) only
- B
(b) only
- C
(c) and (d) only
- D
(c), (d) and (e) only
Examine each statement in the context of genetically engineered (recombinant) human insulin.
(a) Pro-insulin contains an extra stretch (C-peptide) connecting the A and B chains that must be removed to obtain mature insulin. Correct.
(b) Eli Lilly produced the A and B chains separately in E. coli and then chemically combined them through disulphide bonds. Correct.
(c) Insulin used for treating diabetes today is genetically engineered, not extracted from cattle or pigs. Animal-source insulin was used historically but is no longer the standard. The statement does not describe genetically engineered insulin. Incorrect.
(d) Pro-insulin must be processed (C-peptide removed) to yield the mature, functional hormone. Correct.
(e) Allergic reactions to foreign insulin were an issue with animal-derived insulin; recombinant human insulin produces fewer such reactions. So (e) does not apply to genetically engineered insulin. Incorrect.
Therefore the correct statements about genetically engineered insulin are (a), (b), and (d).
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